RESUMO
ABSTRACT Epilepsy is a multifactorial pathology that has allowed the development of various drugs aiming to combat it. This effort was formally initiated in the 1940s when phenytoin began to be used. It eventually turned out to be a drug with great anticonvulsant efficacy. At present, several potentially good new generation anti-seizure medications (ASMs) have been developed. Most of them present more tolerability and less toxic effects. However, they continue to have adverse effects at different levels. In addition, some seizures are difficult to treat with ASMs, representing 30% of the total cases of people who suffer from epilepsy. This review aims to explore the genetic and molecular mechanisms of ASMs neurotoxicity, proposing the study of damage caused by epileptic seizures, in addition to the deterioration generated by anti-seizure drug administration within the central nervous system. It is beyond question that there is a need to develop drugs that lower the lower the risk of secondary and toxic effects of ASMs. Simultaneously, we must find strategies that produce fewer harmful interactions and more health benefits when taking anti-seizure drugs.
RESUMO
Introducción: El nervio dentario inferior es una estructura anatómica de la mandíbula, la cual presenta variaciones como el asa mandibular, ambas estructuras están relacionadas con iatrogenias con tratamientos como cirugías orales, regeneraciones óseas e implantes. El objetivo del presente estudio es evaluar las características del asa mandibular y el agujero mentoniano utilizando tomografía axial computarizada de haz cónico (CBCT) en pacientes del Postgrado de Periodoncia de la Universidad Autónoma de Nuevo León. Material y métodos: Se analizaron un total de 110 CBCT, de los cuales 61 entraron al estudio cumpliendo con los criterios de inclusión, se realizaron cortes transversales utilizando el software On Demand® para identifi car y medir el asa mandibular y localizar la posición del agujero mentoniano de ambos lados separando los grupos por género. Resultados: La prevalencia del asa mandibular fue de 32.8% de 61 CBCT que se analizaron, se observó más comúnmente en hombres y de manera bilateral, y cuando fue unilateral sólo se encontró en el lado derecho, la longitud promedio fue de 6 ± 1 mm. El agujero mentoniano se detectó en mayor porcentaje apical al segundo premolar inferior con un diámetro promedio de 3.5 ± 0.5 mm, alejándose de la raíz del diente adyacente en un promedio de 6 ± 1 mm y del borde de la mandíbula 12.5 mm ± 0.5 mm. Conclusión: Es de suma importancia identifi car las características anatómicas del asa mandibular y localizar la posición del agujero mentoniano durante la planifi cación del tratamiento para evitar complicaciones durante y después del acto quirúrgico (AU)
Introduction: The inferior dental nerve is an anatomical structure of the mandible which presents variations such as the anterior loop, both structures are related to iatrogenies with treatments such as oral surgeries, bone regenerations and implants. The aim of the present study is to evaluate the characteristics of the anterior loop and the mental foramen using cone beam computed tomography (CBCT) in patients of the Graduate Periodontics Program, School of Dentistry, Universidad Autónoma de Nuevo León. Material and methods: 110 CBCT were analyzed of which 61 entered the study fulfi lling the inclusion criteria, cross sections were made using the On Demand® software to identify and measure the anterior loop and locate the position of the mental foramen both sides separating our groups by gender. Results: The prevalence of the anterior loop was 32.8% of 61 CBCT that were analyzed, it was found more commonly in men and bilaterally, and when it was unilateral only found on the right side, the average length was 6 ± 1 mm. The mental hole was found in greater percentage apical to the second lower premolar with an average diameter of 3.5 ± 0.5 mm, moving away from the root of the adjacent tooth by an average of 6 ± 1 mm and from the edge of the mandible 12.5 ± 0.5 mm. Conclusion: It is very important to locate these anatomical structures during treatment planning and avoid complications during and after the surgical act (AU)